Epidemiology and treatment of soft tissue infections
Molecular mechanisms of wound healing
Dr. David Young is Professor of Plastic Surgery at UCSF. His area of expertise includes wound healing, microsurgery, and reconstruction after burns and trauma. His research interests include the molecular mechanisms of wound healing and the epidemiology and treatment of soft tissue infections.
Dr. Young is a graduate of Columbia College and earned a medical degree at the Yale University School of Medicine. He trained in pathology at Cornell Medical College and general surgery at the University of Miami/Jackson Memorial Hospital. He then completed an NIH-NRSA funded research Fellowship at Yale and a Plastic Surgery Fellowship at the University of California, San Francisco.
Dr. Young is primarily interested in the mechanisms and treatments of normal and abnormal wound healing. He is Principal Investigator on a study pertaining to the role of heat shock proteins, homeobox genes, and hypoxia in cutaneous wound healing.
The effects of manipulating of hypoxia inducible proteins, homeobox genes, and heat shock proteins in wound repair are presently under investigation. In vitro and in vivo models of wound repair are used to study the effects of induction and blockage of these proteins on normal and abnormal healing. Expression of many of these proteins is altered in conditions of poor wound healing as found in patients with diabetes.
Dr. Young hopes to understand how these proteins interact during wound healing and to develop novel methods to improve healing. Dr. Young's research is conducted in the UCSF Surgical Research Laboratory at SFGH. The research is currently funded by a RO-1 grant "Diabetes, Hypoxia Inducible Factor-1, and Delayed Wound Healing" from the NIH-NIGMS.
Most recent publications from a total of 26
Sbitany H, Xu X, Hansen SL, Young DM, Hoffman WY. The effects of immunosuppressive medications on outcomes in microvascular free tissue transfer. Plast Reconstr Surg. 2014 Apr; 133(4):552e-8e. View in PubMed
Yamashita K, Yotsuyanagi T, Yamauchi M, Young DM. Klotho mice: a novel wound model of aged skin. Plast Reconstr Surg Glob Open. 2014 Jan; 2(1):e101. View in PubMed
Yang SB, Lee HY, Young DM, Tien AC, Rowson-Baldwin A, Shu YY, Jan YN, Jan LY. Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. J Mol Med (Berl). 2012 May; 90(5):575-85. View in PubMed
Restivo TE, Mace KA, Harken AH, Young DM. Application of the chemokine CXCL12 expression plasmid restores wound healing to near normal in a diabetic mouse model. J Trauma. 2010 Aug; 69(2):392-8. View in PubMed
Young DM, Schenk AK, Yang SB, Jan YN, Jan LY. Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):11074-9. View in PubMed
Mohebali K, Young DM, Hansen SL, Shawo A, Freise CE, Chang DS, Maa J, Harris HW. Open incisional hernia repair at an academic tertiary care medical center. Arch Surg. 2009 Sep; 144(9):848-52. View in PubMed
Mace KA, Restivo TE, Rinn JL, Paquet AC, Chang HY, Young DM, Boudreau NJ. HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells. Stem Cells. 2009 Jul; 27(7):1654-65. View in PubMed
Yu DH, Mace KA, Hansen SL, Boudreau N, Young DM. Effects of decreased insulin-like growth factor-1 stimulation on hypoxia inducible factor 1-alpha protein synthesis and function during cutaneous repair in diabetic mice. Wound Repair Regen. 2007 Sep-Oct; 15(5):628-35. View in PubMed
Mace KA, Yu DH, Paydar KZ, Boudreau N, Young DM. Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair. Wound Repair Regen. 2007 Sep-Oct; 15(5):636-45. View in PubMed
Rajendran PM, Young DM, Maurer T, Chambers HF, Jacobson MA, Harris HW. Antibiotic use in the treatment of soft tissue abscesses: a survey of current practice. Surg Infect (Larchmt). 2007 Apr; 8(2):237-8. View in PubMed
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